Tim-3 Negatively Regulates Cytotoxicity in Exhausted CD8(+) T Cells in HIV Infection

Cytotoxic CD8(+) T cells (CTLs) contain virus infections through the release of granules containing both perforin and granzymes. T cell ‘exhaustion’ is a hallmark of chronic persistent viral infections including HIV. The inhibitory regulatory molecule, T cell Immunoglobulin and Mucin domain containi...

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Autors principals: Sakhdari, Ali, Mujib, Shariq, Vali, Bahareh, Yue, Feng Yun, MacParland, Sonya, Clayton, Kiera, Jones, Richard Bradley, Liu, Jun, Lee, Erika Yue, Benko, Erika, Kovacs, Colin, Gommerman, Jennifer, Kaul, Rupert, Ostrowski, Mario A.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2012
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3390352/
https://ncbi.nlm.nih.gov/pubmed/22792231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0040146
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