CEACAM1 regulates TIM–3–mediated tolerance and exhaustion

T-cell immunoglobulin domain and mucin domain-3 (TIM-3, also known as HAVCR2) is an activation-induced inhibitory molecule involved in tolerance and shown to induce T-cell exhaustion in chronic viral infection and cancers(1–5). Under some conditions, TIM-3 expression has also been shown to be stimul...

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Publicado en:Nature
Main Authors: Huang, Yu-Hwa, Zhu, Chen, Kondo, Yasuyuki, Anderson, Ana C., Gandhi, Amit, Russell, Andrew, Dougan, Stephanie K., Petersen, Britt-Sabina, Melum, Espen, Pertel, Thomas, Clayton, Kiera L., Raab, Monika, Chen, Qiang, Beauchemin, Nicole, Yazaki, Paul J., Pyzik, Michal, Ostrowski, Mario A., Glickman, Jonathan N., Rudd, Christopher E., Ploegh, Hidde L., Franke, Andre, Petsko, Gregory A., Kuchroo, Vijay K., Blumberg, Richard S.
Formato: Artigo
Idioma:Inglês
Publicado: 2014
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4297519/
https://ncbi.nlm.nih.gov/pubmed/25363763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature13848
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