Overexpression of Parkin Ameliorates Dopaminergic Neurodegeneration Induced by 1- Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine in Mice

Mutations in the parkin gene are currently thought to be the most common cause of recessive familial Parkinsonism. Parkin functions as an E3 ligase to regulate protein turnover, and its function in mitochondrial quality control has been reported recently. Overexpression of parkin has been found to p...

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Bibliographic Details
Main Authors: Bian, Minjuan, Liu, Jie, Hong, Xiaoqi, Yu, Mei, Huang, Yufang, Sheng, Zhejin, Fei, Jian, Huang, Fang
Format: Artigo
Language:Inglês
Published: Public Library of Science 2012
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3390003/
https://ncbi.nlm.nih.gov/pubmed/22792139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0039953
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