Opposite Effects of the S4–S5 Linker and PIP(2) on Voltage-Gated Channel Function: KCNQ1/KCNE1 and Other Channels

Voltage-gated potassium (Kv) channels are tetramers, each subunit presenting six transmembrane segments (S1–S6), with each S1–S4 segments forming a voltage-sensing domain (VSD) and the four S5–S6 forming both the conduction pathway and its gate. S4 segments control the opening of the intracellular a...

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Hlavní autoři: Choveau, Frank S., Abderemane-Ali, Fayal, Coyan, Fabien C., Es-Salah-Lamoureux, Zeineb, Baró, Isabelle, Loussouarn, Gildas
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Research Foundation 2012
Témata:
Pharmacology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3389672/
https://ncbi.nlm.nih.gov/pubmed/22787448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2012.00125
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