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The receptor Ly108 functions as a SAP adaptor dependent on-off switch for T cell help to B cells and NKT cell development
Humans and mice deficient in the adaptor protein SAP (Sh2d1a) have a major defect in humoral immunity, due to lack of T cell help for B cells. The role of SAP in this process is incompletely understood. We found that deletion of receptor Ly108 (Slamf6) in CD4(+) T cells reversed the Sh2d1a(−/−) phen...
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| Hauptverfasser: | , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3389310/ https://ncbi.nlm.nih.gov/pubmed/22683125 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2012.05.016 |
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