Bisubstrate analogue inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase: New lead exhibits a distinct binding mode

6-Hydroxymethyl-7,8-dihydropterin pyrophosphokinase (HPPK), a key enzyme in the folate biosynthesis pathway catalyzing the pyrophosphoryl transfer from ATP to 6-hydroxymethyl-7,8-dihydropterin, is an attractive target for developing novel antimicrobial agents. Previously, we studied the mechanism of...

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Autores principales: Shi, Genbin, Shaw, Gary, Li, Yue, Wu, Yan, Yan, Honggao, Ji, Xinhua
Formato: Artigo
Lenguaje:Inglês
Publicado: 2012
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3389233/
https://ncbi.nlm.nih.gov/pubmed/22727779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2012.05.060
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