Loading...

Prdx1 deficiency in mice promotes tissue specific loss of heterozygosity mediated by deficiency in DNA repair and increased oxidative stress

The loss of the H(2)O(2) scavenger protein encoded by Prdx1 in mice leads to an elevation of reactive oxygen species (ROS) and tumorigenesis of different tissues. Loss of heterozygosity (LOH) mutations could initiate tumorigenesis through loss of tumor suppressor gene function in heterozygous somati...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Rani, Vamsi, Neumann, Carola A., Shao, Changshun, Tischfield, Jay A.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3389210/
https://ncbi.nlm.nih.gov/pubmed/22583657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mrfmmm.2012.04.004
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!