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Sumoylation-deficient Prdx6 repairs aberrant Sumoylation-mediated Sp1 dysregulation-dependent Prdx6 repression and cell injury in aging and oxidative stress

Progressive deterioration of antioxidant response in aging is a major culprit in the initiation of age-related pathobiology induced by oxidative stress. We previously reported that oxidative stress leads to a marked reduction in transcription factor Sp1 and its mediated Prdx6 expression in lens epit...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Aging (Albany NY)
Prif Awduron: Chhunchha, Bhavana, Kubo, Eri, Singh, Prerna, Singh, Dhirendra P.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Impact Journals 2018
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6188488/
https://ncbi.nlm.nih.gov/pubmed/30215601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.101547
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