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Aberrant Sumoylation Signaling Evoked by Reactive Oxygen Species Impairs Protective Function of Prdx6 by Destabilization and Repression of its Transcription
Loss of the cytoprotective protein Peroxiredoxin 6 (Prdx6) in cells that are aging or under oxidative stress is known to be linked to pathobiology of many age-related diseases. However, the mechanism by which Prdx6 activity goes awry is largely unknown. Using Prdx6-deficient (Prdx6(−/−)) cells as a...
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| Publicado no: | FEBS J |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4474172/ https://ncbi.nlm.nih.gov/pubmed/24910119 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/febs.12866 |
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