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Positive and Negative Signaling through SLAM receptors regulate Synapse Organization and Thresholds of Cytolysis
X-linked lymphoproliferative syndrome, characterized by fatal responses to Epstein-Barr virus infection, is caused by mutations affecting the adaptor SAP, which links SLAM family receptors to downstream signaling. Although cytotoxic defects in SAP-deficient T cells are documented, the mechanism rema...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3389133/ https://ncbi.nlm.nih.gov/pubmed/22683123 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2012.05.017 |
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