A New Antifibrotic Target of Ac-SDKP: Inhibition of Myofibroblast Differentiation in Rat Lung with Silicosis

BACKGROUND: Myofibroblast differentiation, characterized by α-smooth muscle actin (α-SMA) expression, is a key process in organ fibrosis, and is induced by TGF-β. Here we examined whether an anti-fibrotic agent, N-acetyl-seryl-aspartyl-lysylproline (Ac-SDKP), can regulate induction of TGF-β signalin...

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Detalhes bibliográficos
Main Authors: Xu, Hong, Yang, Fang, Sun, Ying, Yuan, Yuan, Cheng, Hua, Wei, Zhongqiu, Li, Shuyu, Cheng, Tan, Brann, Darrell, Wang, Ruimin
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3389005/
https://ncbi.nlm.nih.gov/pubmed/22802960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0040301
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