Dibutyryl-cAMP attenuates pulmonary fibrosis by blocking myofibroblast differentiation via PKA/CREB/CBP signaling in rats with silicosis

BACKGROUND: Myofibroblasts play a major role in the synthesis of extracellular matrix (ECM) and the stimulation of these cells is thought to play an important role in the development of silicosis. The present study was undertaken to investigate the anti-fibrotic effects of dibutyryl-cAMP (db-cAMP) o...

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Detalhes bibliográficos
Publicado no:Respir Res
Main Authors: Liu, Yan, Xu, Hong, Geng, Yucong, Xu, Dingjie, Zhang, Lijuan, Yang, Yi, Wei, Zhongqiu, Zhang, Bonan, Li, Shifeng, Gao, Xuemin, Wang, Ruimin, Zhang, Xianghong, Brann, Darrell, Yang, Fang
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5320641/
https://ncbi.nlm.nih.gov/pubmed/28222740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12931-017-0523-z
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