Low- and room-temperature X-ray structures of protein kinase A ternary complexes shed new light on its activity

Post-translational protein phosphorylation by protein kinase A (PKA) is a ubiquitous signalling mechanism which regulates many cellular processes. A low-temperature X-ray structure of the ternary complex of the PKA catalytic subunit (PKAc) with ATP and a 20-residue peptidic inhibitor (IP20) at the p...

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Detalles Bibliográficos
Main Authors: Kovalevsky, Andrey Y., Johnson, Hanna, Hanson, B. Leif, Waltman, Mary Jo, Fisher, S. Zoe, Taylor, Susan, Langan, Paul
Formato: Artigo
Idioma:Inglês
Publicado: International Union of Crystallography 2012
Assuntos:
Research Papers
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3388813/
https://ncbi.nlm.nih.gov/pubmed/22751671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S0907444912014886
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