Group I and II mammalian PAKs have different modes of activation by Cdc42

p21-activated kinases (PAKs) are Cdc42 effectors found in metazoans, fungi and protozoa. They are subdivided into PAK1-like (group I) or PAK4-like (group II) kinases. Human PAK4 is widely expressed and its regulatory mechanism is unknown. We show that PAK4 is strongly inhibited by a newly identified...

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Bibliographische Detailangaben
Hauptverfasser: Baskaran, Yohendran, Ng, Yuen-Wai, Selamat, Widyawilis, Ling, Felicia Tay Pei, Manser, Ed
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2012
Schlagworte:
Scientific Reports
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3388789/
https://ncbi.nlm.nih.gov/pubmed/22653441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2012.75
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