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Enhancement of proliferation and downregulation of TRAIL expression on CD8(+) T cells by IL-21

Mounting evidence indicates that the cytokine IL-21 can significantly enhance the survival of CD8(+) T lymphocytes. Given that CD4(+) T lymphocytes constitute the main cellular source for IL-21 in vivo, it is tempting to speculate a direct role in mediating the “help” provided by these CD4(+) T cell...

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Detalhes bibliográficos
Main Authors: Melief, Cornelis J. M., Schoenberger, Stephen P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3388532/
https://ncbi.nlm.nih.gov/pubmed/21064084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201041076
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