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Age and Region-Specific Responses of Microglia, but not Astrocytes, Suggest a Role in Selective Vulnerability of Dopamine Neurons After 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Exposure in Monkeys

Little is known about the effects of aging, the strongest risk factor for Parkinson’s disease (PD), on glial responses to dopamine (DA) neuron degeneration in midbrain subregions that display selective vulnerability to degeneration. We evaluated the impact of aging on astrocytes and microglia in a r...

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Detalhes bibliográficos
Main Authors: KANAAN, NICHOLAS M., KORDOWER, JEFFREY H., COLLIER, TIMOTHY J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3388430/
https://ncbi.nlm.nih.gov/pubmed/18484101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/glia.20690
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