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Coordination between proteasome impairment and caspase activation leading to TAU pathology: neuroprotection by cAMP
Neurofibrillary tangles (NFTs) are hallmarks of Alzheimer's disease (AD). The main component of NFTs is TAU, a highly soluble microtubule-associated protein. However, when TAU is cleaved at Asp421 by caspases it becomes prone to aggregation leading to NFTs. What triggers caspase activation resu...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2012
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3388240/ https://ncbi.nlm.nih.gov/pubmed/22717581 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2012.70 |
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