Acute hypoxia induces apoptosis of pancreatic β-cell by activation of the unfolded protein response and upregulation of CHOP

The success of pancreatic β-cells transplantation to treat type 1 diabetes has been hindered by massive β-cell dysfunction and loss of β-cells that follows the procedure. Hypoxia-mediated cell death has been considered one of the main difficulties that must be overcome for transplantation to be rega...

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Bibliographische Detailangaben
Hauptverfasser: Zheng, X, Wang, X, Ma, Z, Gupta Sunkari, V, Botusan, I, Takeda, T, Björklund, A, Inoue, M, Catrina, S-B, Brismar, K, Poellinger, L, Pereira, T S
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2012
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3388238/
https://ncbi.nlm.nih.gov/pubmed/22695615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2012.66
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