Constitutive Notch2 signaling in neural stem cells promotes tumorigenic features and astroglial lineage entry

Recent studies identified a highly tumorigenic subpopulation of glioma stem cells (GSCs) within malignant gliomas. GSCs are proposed to originate from transformed neural stem cells (NSCs). Several pathways active in NSCs, including the Notch pathway, were shown to promote proliferation and tumorigen...

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Hlavní autoři: Tchorz, J S, Tome, M, Cloëtta, D, Sivasankaran, B, Grzmil, M, Huber, R M, Rutz-Schatzmann, F, Kirchhoff, F, Schaeren-Wiemers, N, Gassmann, M, Hemmings, B A, Merlo, A, Bettler, B
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2012
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3388237/
https://ncbi.nlm.nih.gov/pubmed/22717580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2012.65
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