Constitutive Notch2 signaling in neural stem cells promotes tumorigenic features and astroglial lineage entry

Recent studies identified a highly tumorigenic subpopulation of glioma stem cells (GSCs) within malignant gliomas. GSCs are proposed to originate from transformed neural stem cells (NSCs). Several pathways active in NSCs, including the Notch pathway, were shown to promote proliferation and tumorigen...

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Detalles Bibliográficos
Autores principales: Tchorz, J S, Tome, M, Cloëtta, D, Sivasankaran, B, Grzmil, M, Huber, R M, Rutz-Schatzmann, F, Kirchhoff, F, Schaeren-Wiemers, N, Gassmann, M, Hemmings, B A, Merlo, A, Bettler, B
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2012
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3388237/
https://ncbi.nlm.nih.gov/pubmed/22717580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2012.65
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