The Hsp90 inhibitor NVP-AUY922-AG inhibits NF-κB signaling, overcomes microenvironmental cytoprotection and is highly synergistic with fludarabine in primary CLL cells

Heat shock protein 90 (Hsp90) is a molecular chaperone required for the stability and function of multiple over-expressed signaling proteins that promote growth and survival in cancer cells. Chronic lymphocytic leukaemia (CLL) is characterized by increased expression of several Hsp90 client proteins...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Walsby, Elisabeth, Pearce, Lawrence, Burnett, Alan K., Fegan, Chris, Pepper, Chris
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Impact Journals LLC 2012
Gaiak:
Research Papers
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3388182/
https://ncbi.nlm.nih.gov/pubmed/22619113
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