Inhibition of α-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors

Two Krebs cycle genes, fumarate hydratase (FH) and succinate dehydrogenase (SDH), are mutated in a subset of human cancers, leading to accumulation of their substrates, fumarate and succinate, respectively. Here we demonstrate that fumarate and succinate are competitive inhibitors of multiple α-keto...

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Detalhes bibliográficos
Main Authors: Xiao, Mengtao, Yang, Hui, Xu, Wei, Ma, Shenghong, Lin, Huaipeng, Zhu, Honguang, Liu, Lixia, Liu, Ying, Yang, Chen, Xu, Yanhui, Zhao, Shimin, Ye, Dan, Xiong, Yue, Guan, Kun-Liang
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2012
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3387660/
https://ncbi.nlm.nih.gov/pubmed/22677546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.191056.112
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