Angptl4 protects against severe pro-inflammatory effects of dietary saturated fat by inhibiting lipoprotein lipase-dependent uptake of fatty acids in mesenteric lymph node macrophages

Dietary saturated fat is linked to numerous chronic diseases, including cardiovascular disease. Here we show that the lipoprotein lipase inhibitor Angptl4 protects against the pronounced pro-inflammatory effects of dietary saturated fat. Strikingly, in mice lacking Angptl4, dietary saturated fat ind...

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Detalhes bibliográficos
Main Authors: Lichtenstein, Laeticia, Mattijssen, Frits, de Wit, Nicole J., Georgiadi, Anastasia, Hooiveld, Guido J., van der Meer, Roelof, He, Yin, Qi, Ling, Köster, Anja, Tamsma, Jouke T., Tan, Nguan Soon, Müller, Michael, Kersten, Sander
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3387545/
https://ncbi.nlm.nih.gov/pubmed/21109191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2010.11.002
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