Induction of pro-apoptotic antibodies to triple negative breast cancer by vaccination with TRAIL death receptor DR5 DNA

TNF-Related Apoptosis Inducing Ligand Receptor 2 (TRAIL-R2 or DR5) is expressed at elevated levels in a broad range of solid tumors to mediate apoptotic signals from TRAIL or agonist antibodies. We tested the hypothesis that DR5 DNA vaccination will induce pro-apoptotic antibody to trigger apoptosis...

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Main Authors: Piechocki, Marie P., Wu, Gen Sheng, Jones, Richard F., Jacob, Jennifer B., Gibson, Heather, Ethier, Stephen P., Abrams, Judith, Yagita, Hideo, Venuprasad, K, Wei, Wei-Zen
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3387508/
https://ncbi.nlm.nih.gov/pubmed/22419388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.27534
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