Deletion of the Scl +19 enhancer increases the blood stem cell compartment without affecting the formation of mature blood lineages

The stem cell leukemia (Scl)/Tal1 gene is essential for normal blood and endothelial development, and is expressed in hematopoietic stem cells (HSCs), progenitors, erythroid, megakaryocytic, and mast cells. The Scl +19 enhancer is active in HSCs and progenitor cells, megakaryocytes, and mast cells,...

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Autors principals: Spensberger, Dominik, Kotsopoulou, Ekaterini, Ferreira, Rita, Broccardo, Cyril, Scott, Linda M., Fourouclas, Nasios, Ottersbach, Katrin, Green, Anthony R., Göttgens, Berthold
Format: Artigo
Idioma:Inglês
Publicat: Elsevier Science Inc 2012
Matèries:
Stem Cells
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3387379/
https://ncbi.nlm.nih.gov/pubmed/22401818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exphem.2012.02.006
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