Multifunctional T cell reactivity to native and glycosylated type-II collagen in rheumatoid arthritis

OBJECTIVE: Type II collagen (CII) is a cartilage-specific protein to which a loss of immune tolerance may trigger autoimmune reactions and cause arthritis. The major T cell epitope on CII, aa259-273, can be presented by several HLA-DRB1*04 alleles in its native or posttranslational-glycosylated form...

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Autori principali: Snir, Omri, Bäcklund, Johan, Boström, Julia, Andersson, Ida, Kihlberg, Jan, Buckner, Jane H, Klareskog, Lars, Holmdahl, Rikard, Malmström, Vivianne
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3387353/
https://ncbi.nlm.nih.gov/pubmed/22392632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.34459
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