Gene Disruption of the Calcium Channel Orai1 Results in Inhibition of Osteoclast and Osteoblast Differentiation and Impairs Skeletal Development

Calcium signaling plays a central role in the regulation of bone cells, though uncertainty remains with regard to the channels involved. In previous studies, we determined that the calcium channel Orai1 was required for the formation of multinucleated osteoclasts in vitro. To define the skeletal fun...

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Autori principali: Robinson, Lisa J., Mancarella, Salvatore, Songsawad, Duangrat, Tourkova, Irina L., Barnett, John B., Gill, Donald L., Soboloff, Jonathan, Blair, Harry C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3387291/
https://ncbi.nlm.nih.gov/pubmed/22546867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/labinvest.2012.72
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