NOTCH1 Signaling Promotes Human T-Cell Acute Lymphoblastic Leukemia Initiating Cell Regeneration in Supportive Niches

BACKGROUND: Leukemia initiating cells (LIC) contribute to therapeutic resistance through acquisition of mutations in signaling pathways, such as NOTCH1, that promote self-renewal and survival within supportive niches. Activating mutations in NOTCH1 occur commonly in T cell acute lymphoblastic leukem...

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Detalhes bibliográficos
Main Authors: Ma, Wenxue, Gutierrez, Alejandro, Goff, Daniel J., Geron, Ifat, Sadarangani, Anil, Jamieson, Christina A. M., Court, Angela C., Shih, Alice Y., Jiang, Qingfei, Wu, Christina C., Li, Kang, Smith, Kristen M., Crews, Leslie A., Gibson, Neil W., Deichaite, Ida, Morris, Sheldon R., Wei, Ping, Carson, Dennis A., Look, A. Thomas, Jamieson, Catriona H. M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3387267/
https://ncbi.nlm.nih.gov/pubmed/22768113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0039725
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