HS1, a Lyn Kinase Substrate, Is Abnormally Expressed in B-Chronic Lymphocytic Leukemia and Correlates with Response to Fludarabine-Based Regimen

In B-Chronic Lymphocytic Leukemia (B-CLL) kinase Lyn is overexpressed, active, abnormally distributed, and part of a cytosolic complex involving hematopoietic lineage cell-specific protein 1 (HS1). These aberrant properties of Lyn could partially explain leukemic cells’ defective apoptosis, directly...

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Autors principals: Frezzato, Federica, Gattazzo, Cristina, Martini, Veronica, Trimarco, Valentina, Teramo, Antonella, Carraro, Samuela, Cabrelle, Anna, Ave, Elisa, Facco, Monica, Zambello, Renato, Tibaldi, Elena, Brunati, Anna Maria, Semenzato, Gianpietro, Trentin, Livio
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2012
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3387232/
https://ncbi.nlm.nih.gov/pubmed/22768161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0039902
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