Mannose 6-Phosphate Receptor and Sortilin Mediated Endocytosis of α-Galactosidase A in Kidney Endothelial Cells

Prominent vasculopathy in Fabry disease patients is caused by excessive intracellular accumulation of globotriaosylceramide (GL-3) throughout the vascular endothelial cells causing progressive cerebrovascular, cardiac and renal impairments. The vascular lesions lead to myocardial ischemia, atherogen...

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Detalhes bibliográficos
Main Authors: Prabakaran, Thaneas, Nielsen, Rikke, Satchell, Simon C., Mathieson, Peter W., Feldt-Rasmussen, Ulla, Sørensen, Søren S., Christensen, Erik I.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3386966/
https://ncbi.nlm.nih.gov/pubmed/22768187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0039975
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