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Identification of mannose 6-phosphate in glycoproteins that inhibit the assimilation of β-galactosidase by fibroblasts

Bovine testicular β-galactosidase (β-D-galactoside galactohydrolase, EC 3.2.1.23) is rapidly and selectively assimilated by human skin fibroblasts. The assimilation of the enzyme is strongly inhibited by mannose 6-phosphate and by a glycoprotein fraction isolated from bovine testes (glycoprotein inh...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Distler, Jack, Hieber, Virginia, Sahagian, Gary, Schmickel, Roy, Jourdian, George W.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 1979
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Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC411547/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/116230/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.76.9.4235
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