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CD28 Costimulation Regulates Genome-Wide Effects on Alternative Splicing

CD28 is the major costimulatory receptor required for activation of naïve T cells, yet CD28 costimulation affects the expression level of surprisingly few genes over those altered by TCR stimulation alone. Alternate splicing of genes adds diversity to the proteome and contributes to tissue-specific...

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Hlavní autoři: Butte, Manish J., Lee, Sun Jung, Jesneck, Jonathan, Keir, Mary E., Haining, W. Nicholas, Sharpe, Arlene H.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2012
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3386953/
https://ncbi.nlm.nih.gov/pubmed/22768209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0040032
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