A Common Ca(2+)-Driven Interdomain Module Governs Eukaryotic NCX Regulation

Na(+)/Ca(2+) exchanger (NCX) proteins mediate Ca(2+)-fluxes across the cell membrane to maintain Ca(2+) homeostasis in many cell types. Eukaryotic NCX contains Ca(2+)-binding regulatory domains, CBD1 and CBD2. Ca(2+) binding to a primary sensor (Ca3-Ca4 sites) on CBD1 activates mammalian NCXs, where...

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Hlavní autoři: Giladi, Moshe, Sasson, Yehezkel, Fang, Xianyang, Hiller, Reuben, Buki, Tal, Wang, Yun-Xing, Hirsch, Joel A., Khananshvili, Daniel
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2012
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3386913/
https://ncbi.nlm.nih.gov/pubmed/22768191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0039985
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