Astrocyte-derived VEGF-A drives blood-brain barrier disruption in CNS inflammatory disease

In inflammatory CNS conditions such as multiple sclerosis (MS), current options to treat clinical relapse are limited, and more selective agents are needed. Disruption of the blood-brain barrier (BBB) is an early feature of lesion formation that correlates with clinical exacerbation, leading to edem...

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Main Authors: Argaw, Azeb Tadesse, Asp, Linnea, Zhang, Jingya, Navrazhina, Kristina, Pham, Trinh, Mariani, John N., Mahase, Sean, Dutta, Dipankar J., Seto, Jeremy, Kramer, Elisabeth G., Ferrara, Napoleone, Sofroniew, Michael V., John, Gareth R.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 2012
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3386814/
https://ncbi.nlm.nih.gov/pubmed/22653056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI60842
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