Fucose content of monoclonal antibodies can be controlled by culture medium osmolality for high antibody-dependent cellular cytotoxicity

Antibody-dependent cellular cytotoxicity (ADCC) is dependent on the fucose content of oligosaccharides bound to monoclonal antibodies (MAbs). As MAbs with a low fucose content exhibit high ADCC activity, it is important to control the defucosylation levels (deFuc%) of MAbs and to analyze the factors...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Konno, Yoshinobu, Kobayashi, Yuki, Takahashi, Ken, Takahashi, Eiji, Sakae, Shinji, Wakitani, Masako, Yamano, Kazuya, Suzawa, Toshiyuki, Yano, Keiichi, Ohta, Toshio, Koike, Masamichi, Wakamatsu, Kaori, Hosoi, Shinji
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Springer Netherlands 2011
Gaiak:
JAACT Special Issue
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3386387/
https://ncbi.nlm.nih.gov/pubmed/21870215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10616-011-9377-2
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