Fucose content of monoclonal antibodies can be controlled by culture medium osmolality for high antibody-dependent cellular cytotoxicity

Antibody-dependent cellular cytotoxicity (ADCC) is dependent on the fucose content of oligosaccharides bound to monoclonal antibodies (MAbs). As MAbs with a low fucose content exhibit high ADCC activity, it is important to control the defucosylation levels (deFuc%) of MAbs and to analyze the factors...

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Detalhes bibliográficos
Main Authors: Konno, Yoshinobu, Kobayashi, Yuki, Takahashi, Ken, Takahashi, Eiji, Sakae, Shinji, Wakitani, Masako, Yamano, Kazuya, Suzawa, Toshiyuki, Yano, Keiichi, Ohta, Toshio, Koike, Masamichi, Wakamatsu, Kaori, Hosoi, Shinji
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Netherlands 2011
Assuntos:
JAACT Special Issue
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3386387/
https://ncbi.nlm.nih.gov/pubmed/21870215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10616-011-9377-2
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