The Rad4(TopBP1) ATR-Activation Domain Functions in G1/S Phase in a Chromatin-Dependent Manner

DNA damage checkpoint activation can be subdivided in two steps: initial activation and signal amplification. The events distinguishing these two phases and their genetic determinants remain obscure. TopBP1, a mediator protein containing multiple BRCT domains, binds to and activates the ATR/ATRIP co...

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Autori principali: Lin, Su-Jiun, Wardlaw, Christopher P., Morishita, Takashi, Miyabe, Izumi, Chahwan, Charly, Caspari, Thomas, Schmidt, Ulrike, Carr, Antony M., Garcia, Valerie
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2012
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3386226/
https://ncbi.nlm.nih.gov/pubmed/22761595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1002801
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