Rosiglitazone and AS601245 Decrease Cell Adhesion and Migration through Modulation of Specific Gene Expression in Human Colon Cancer Cells

PPARs are nuclear receptors activated by ligands. Activation of PPARγ leads to a reduction of adhesion and motility in some cancer models. PPARγ transcriptional activity can be negatively regulated by JNK-mediated phosphorylation. We postulated that the use of agents able to inhibit JNK activity cou...

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Main Authors: Cerbone, Angelo, Toaldo, Cristina, Minelli, Rosalba, Ciamporcero, Eric, Pizzimenti, Stefania, Pettazzoni, Piergiorgio, Roma, Guglielmo, Dianzani, Mario Umberto, Ullio, Chiara, Ferretti, Carlo, Dianzani, Chiara, Barrera, Giuseppina
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2012
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3386191/
https://ncbi.nlm.nih.gov/pubmed/22761953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0040149
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