Rosiglitazone and AS601245 Decrease Cell Adhesion and Migration through Modulation of Specific Gene Expression in Human Colon Cancer Cells

PPARs are nuclear receptors activated by ligands. Activation of PPARγ leads to a reduction of adhesion and motility in some cancer models. PPARγ transcriptional activity can be negatively regulated by JNK-mediated phosphorylation. We postulated that the use of agents able to inhibit JNK activity cou...

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Autors principals: Cerbone, Angelo, Toaldo, Cristina, Minelli, Rosalba, Ciamporcero, Eric, Pizzimenti, Stefania, Pettazzoni, Piergiorgio, Roma, Guglielmo, Dianzani, Mario Umberto, Ullio, Chiara, Ferretti, Carlo, Dianzani, Chiara, Barrera, Giuseppina
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2012
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3386191/
https://ncbi.nlm.nih.gov/pubmed/22761953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0040149
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