PPARγ ligands inhibit telomerase activity and hTERT expression through modulation of the Myc/Mad/Max network in colon cancer cells

In human cells the length of telomeres depends on telomerase activity. This activity and the expression of the catalytic subunit of human telomerase reverse transcriptase (hTERT) is strongly up-regulated in most human cancers. hTERT expression is regulated by different transcription factors, such as...

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Main Authors: Toaldo, Cristina, Pizzimenti, Stefania, Cerbone, Angelo, Pettazzoni, Piergiorgio, Menegatti, Elisa, Daniela, Berardi, Minelli, Rosalba, Giglioni, Barbara, Dianzani, Mario Umberto, Ferretti, Carlo, Barrera, Giuseppina
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2010
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3828851/
https://ncbi.nlm.nih.gov/pubmed/19912441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1582-4934.2009.00966.x
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