Fuzzy Tandem Repeats Containing p53 Response Elements May Define Species-Specific p53 Target Genes

Evolutionary forces that shape regulatory networks remain poorly understood. In mammals, the Rb pathway is a classic example of species-specific gene regulation, as a germline mutation in one Rb allele promotes retinoblastoma in humans, but not in mice. Here we show that p53 transactivates the Retin...

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Autori principali: Simeonova, Iva, Lejour, Vincent, Bardot, Boris, Bouarich-Bourimi, Rachida, Morin, Aurélie, Fang, Ming, Charbonnier, Laure, Toledo, Franck
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2012
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3386156/
https://ncbi.nlm.nih.gov/pubmed/22761580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1002731
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