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Mechanism of enhanced mechanical stability of a minimal RNA kissing complex elucidated by nonequilibrium molecular dynamics simulations

An RNA kissing loop from the Moloney murine leukemia virus (MMLV) exhibits unusual mechanical stability despite having only two intermolecular base pairs. Mutations at this junction have been shown to destabilize genome dimerization, with concomitant reductions in viral packaging efficiency and infe...

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Detalhes bibliográficos
Main Authors: Chen, Alan A., García, Angel E.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3386141/
https://ncbi.nlm.nih.gov/pubmed/22623526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1119552109
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