Inhibition of S-phase kinase-associated protein 2 (Skp2) reprograms and converts diabetogenic T cells to Foxp3(+) regulatory T cells

Autoreactive pathogenic T cells (Tpaths) and regulatory T cells (Tregs) express a distinct gene profiles; however, the genes and associated genetic/signaling pathways responsible for the functional determination of Tpaths vs. Tregs remain unknown. Here we show that Skp2, an E3 ubiquitin ligase that...

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Hlavní autoři: Wang, Ding, Qin, Hanjun, Du, Weiting, Shen, Yueh-Wei, Lee, Wen-Hui, Riggs, Arthur D., Liu, Chih-Pin
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2012
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3386130/
https://ncbi.nlm.nih.gov/pubmed/22645357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1207293109
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