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PI3K/AKT pathway activation in acute myeloid leukaemias is not associated with AKT1 pleckstrin homology domain mutation

Despite its’ central role, the precise mechanisms of the phosphoinositide 3-kinase/Akt (PI3K)/Akt pathway activation in acute myeloid leukaemia (AML) have not been elucidated. Recently, a recurrent novel AKT1 pleckstrin homology domain (PHD) mutation leading to membrane translocation, constitutive A...

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Bibliografische gegevens
Hoofdauteurs: Tibes, Raoul, Kornblau, Steven M., Qiu, Yihua, Mousses, Spyro M., Robbins, Christiane, Moses, Tracy, Carpten, John D.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2007
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3385948/
https://ncbi.nlm.nih.gov/pubmed/18053070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2141.2007.06920.x
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