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Spatiotemporal Dysfunction of the Vascular Permeability Barrier in Transgenic Mice with Sickle Cell Disease

Sickle cell disease (SCD) is characterized by chronic intravascular hemolysis that generates excess cell-free hemoglobin in the blood circulation. Hemoglobin causes multiple endothelial dysfunctions including increased vascular permeability, impaired reactivity to vasoactive agonists, and increased...

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Detalhes bibliográficos
Main Authors: Ghosh, Samit, Tan, Fang, Ofori-Acquah, Solomon F.
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3384933/
https://ncbi.nlm.nih.gov/pubmed/22778926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2012/582018
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