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Effects of Somatic Mutations in the C-Terminus of Insulin-Like Growth Factor 1 Receptor on Activity and Signaling

The insulin-like growth factor I receptor (IGF1R) is overexpressed in several forms of human cancer, and it has emerged as an important target for anticancer drug design. Cancer genome sequencing efforts have recently identified three somatic mutations in IGF1R: A1374V, a deletion of S1278 in the C-...

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Sonraí Bibleagrafaíochta
Main Authors: Craddock, Barbara P., Miller, W. Todd
Formáid: Artigo
Teanga:Inglês
Foilsithe: Hindawi Publishing Corporation 2012
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3384887/
https://ncbi.nlm.nih.gov/pubmed/22778948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2012/804801
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