Sublingual Immunization with a Live Attenuated Influenza A Virus Lacking the Nonstructural Protein 1 Induces Broad Protective Immunity in Mice

The nonstructural protein 1 (NS1) of influenza A virus (IAV) enables the virus to disarm the host cell type 1 IFN defense system. Mutation or deletion of the NS1 gene leads to attenuation of the virus and enhances host antiviral response making such live-attenuated influenza viruses attractive vacci...

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Bibliographische Detailangaben
Hauptverfasser: Park, Hae-Jung, Ferko, Boris, Byun, Young-Ho, Song, Joo-Hye, Han, Gye-Yeong, Roethl, Elisabeth, Egorov, Andrej, Muster, Thomas, Seong, Baiklin, Kweon, Mi-Na, Song, Manki, Czerkinsky, Cecil, Nguyen, Huan H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2012
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3384633/
https://ncbi.nlm.nih.gov/pubmed/22761928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0039921
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