Triological Society Thesis Preclinical Validation of AR42, a Novel Histone Deacetylase Inhibitor, as Treatment for Vestibular Schwannomas

OBJECTIVE/HYPOTHESIS: Recent studies indicate that vestibular schwannomas (VS) rely on PI3-kinase/AKT activation to promote cell proliferation and survival; therefore, targeting AKT may provide new therapeutic options. We have previously shown that AR42, a novel histone deacetylase inhibitor, potent...

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Hauptverfasser: Jacob, Abraham, Oblinger, Janet, Bush, Matthew L., Brendel, Victoria, Santarelli, Griffin, Chaudhury, Abhik R., Kulp, Samuel, La Perle, Krista M. D., Chen, Ching-Shih, Chang, Long-Sheng, Welling, D. Bradley
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3384504/
https://ncbi.nlm.nih.gov/pubmed/22109824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/lary.22392
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