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Functional inhibition of osteoblastic cells in an in vivo mouse model of myeloid leukemia

Pancytopenia is a major cause of morbidity in acute myeloid leukemia (AML), yet its cause is unclear. Normal osteoblastic cells have been shown to support hematopoiesis. To define the effects of leukemia on osteoblastic cells, we used an immunocompetent murine model of AML. Leukemic mice had inhibit...

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Hlavní autoři: Frisch, Benjamin J., Ashton, John M., Xing, Lianping, Becker, Michael W., Jordan, Craig T., Calvi, Laura M.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2012
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3384480/
https://ncbi.nlm.nih.gov/pubmed/21957195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-04-348151
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