Activation of Multiple ERBB Family Receptors Mediates Glioblastoma Cancer Stem-like Cell Resistance to EGFR-Targeted Inhibition

Epidermal growth factor receptor (EGFR) signaling is strongly implicated in glioblastoma (GBM) tumorigenesis. However, molecular agents targeting EGFR have demonstrated minimal efficacy in clinical trials, suggesting the existence of GBM resistance mechanisms. GBM cells with stem-like properties (CS...

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Detaylı Bibliyografya
Asıl Yazarlar: Clark, Paul A, Iida, Mari, Treisman, Daniel M, Kalluri, Haviryaji, Ezhilan, Sathyapriya, Zorniak, Michael, Wheeler, Deric L, Kuo, John S
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Neoplasia Press Inc. 2012
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3384429/
https://ncbi.nlm.nih.gov/pubmed/22745588
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